CYB5R2 and metastatic malignant neoplasm in the lymph nodes: Clinical characters of the 50 NPC patients were collected, and we found a significant association of CYB5R2 promoter hypermethylation with the clinico-pathological variable lymph node metastasis (P < 0.05), however, there was no significant correlation to age, sex, cancer stage, or pathological subtypes (Table 2).