In comparison, Sar1B mutations in CMRD culminate in the production of abnormally large chylomicrons (90) and a lipid phenotype resembling that observed in the recessively inherited lipoprotein production disorder, abetalipoproteinemia; specifically, enterocytes from CMRD patients contain large cytosolic lipid droplets, even in the fasting state (90). The gene discussed is SAR1B; the disease is chylomicron retention disease.