Genes down-regulated in cultured CLL lymphocytes included pro-apoptotic BCL2 family members: BAD, BNIP1, and BNIP3; genes coding for repair proteins: GADD45 and ERCC6; growth factor/chemokine receptors: IGFBP1, IGFBP2, and IGFBP6; genes for antioxidant enzymes: MGST12, GSTP1, and GPX1; and gene coding for death receptor FAS (Table 4). The gene discussed is IGFBP6; the disease is B-cell chronic lymphocytic leukemia.