CD28 and achondroplasia: The ACH patients showed positive correlations between ALT and inflammatory costimulatory proteins CD80, CD83, CD28, CD40 and ICAM-1 (p < 0.05), but negative correlations between CTLA-4 and inflammatory costimulatory proteins CD80, CD86, CD83, CD28, CD40 and ICAM-1 (p < 0.05).