However, Dan et al (9), demonstrated that both PI3K inhibitors, LY294002 and ZSTK474, suppress proliferation by decreasing expression of CycD1 and Ki-67, while they do not increase apoptosis in prostate cancer, lung cancer, glioblastoma and colorectal cancer cell lines and in human cancer xenografts. This evidence concerns the gene MKI67 and colorectal cancer.