To investigate whether controlling prehypertension by short- or long-term drug administration would benefit brain structure as well as prevent stroke, and to explore which drug, losartan (AT1R blocker) or amlodipine (calcium channel blocker), had more protective effects on brain when used for prehypertension treatment, we utilized the well-established SHRSP as a model system. Here, AGTR1 is linked to stroke disorder.