GO terms regarding inflammatory response play an important role in CTEPH; a number of studies have reported CRP as a predictor of adverse outcome in pulmonary arterial hypertension (43), and IL-6-mediated systemic inflammatory cascades may also be involved in the regulation of peripheral vascular tone following pulmonary thromboendarterectomy (PTE) (44). Here, CRP is linked to pulmonary arterial hypertension.