Given the tumor suppressor activity of Notch signaling in SCC (Proweller et al., 2006; Lefort et al., 2007; Kolev et al., 2008; Agrawal et al., 2011; Stransky et al., 2011), Ets1's ability to block to Notch activity may be important for its pro-oncogenic effects. The gene discussed is ETS1; the disease is neoplasm.