SOD3 and Alzheimer disease: Sod3 RNAi improved climbing (Fig. 4g and Supplementary Fig. S3) and survival in AD flies; median survival for Aβarc Sod3-RNAi flies was 35 days vs. 31 days for control Aβarc flies (Log-rank test, P < 0.0001: Fig. 4h and Supplementary Fig. S3), and this appeared to correlate with significantly decreased Sod3-RE mRNA levels (Fig. 4f).