Far from the severe HF patients of PRAISE-2, those from PHFS demonstrated that sST2 evaluation had a predictive 1-year mortality/transplantation rate similar at NT-proBNP one: the ROC curves showed comparable predictive values between the two biomarkers (sST2 AUC: 0.75, 95% CI, 0.69 to 0.79 vs. NT-proBNP AUC: 0.77, 95% CI, 0.72 to 0.81; p = 0.24) [41]. The gene discussed is NPPB; the disease is hydrops fetalis.