The Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department (PRIDE) project was a prospective, blinded study, aimed at evaluating sST2, amino-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) concentrations in 599 dyspnoeic subjects with and without acute destabilized HF admitted to the emergency department of the Massachussets General Hospital [26]. This evidence concerns the gene CRP and hydrops fetalis.