Recently, they found that HSYA antagonized tumor angiogenesis may be related to protein expression inhibition of VEGF, and HIF-1α and weakening the phosphorylation of KDR protein and its gene expression to inhibit the activation of endotheliocyte and impede the induction of tumor oxygen-poor microenvironment to angiogenesis [125]. Here, HIF1A is linked to neoplasm.