CD38 and B-cell chronic lymphocytic leukemia: In an independent cohort of 71 consecutive untreated CD38- CLL with normal FISH or isolated 13q−, a lower miR125a-5p expression was associated with a shorter TTFT both in univariate and multivariate analysis (p=0.003 and 0.016, respectively) and with a higher prevalence of mutations (7/12 vs 0/8, p=0.015) as assessed by next-generation sequencing.