The work by Kusy et al. [36] lends further support to this hypothesis evaluating the gene expression profile of two T-ALL cell lines in basal conditions and after TAL1 or NKX3.1 silencing by RNA interference: in the cell line showing high levels of TAL1 protein (Jurkat), knockdown of TAL1 or of its downstream effector NKX3.1 significantly down-regulates MYCN expression (derived from the analysis of published gene expression data). The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.