The profiles of HER-2/neu and p53 transcripts suggested their involvement in gender-related rhabdomyo sarcoma genesis in BALB-p53Neu mice: in the urethral tissue, male mice expressed HER-2/neu about 15 times more than female mice, and expressed p53 about two times less than female mice (Figure 1). This evidence concerns the gene ERBB2 and sarcoma.