Such structures were not detected in any of three control non-ALS subjects (Fig. 8A), nor in three sALS cases including one with confirmed presence of TDP-43 inclusions (Fig. 8C, sALS-TDP), nor in an ALS-SOD1 case (Fig. 8C, ALS-SOD1). Here, SOD1 is linked to amyotrophic lateral sclerosis.