We have previously reported that Dasatinib induced endoplasmic reticulum stress as well as autophagy on wild type p53 samples, furthermore we indicated a synergistic effect of pifithrin-a, 3-MA or Chloroquine on Dasatinib cytotoxicity in p53 proficient CLL cells [68]. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.