Here the two established subpopulations are p53 proficient CLL cells and we found that endoplasmic reticulum stress as well as ROS were induced by the drug only in Dasatinib resistant cells (Supplementary FIGURE 3) though neither the use of Salubrinal, an inhibitor of eIF2a dephosphorylation and ER stress-mediated apoptosis, nor NAC, a ROS scavenger, affected Dasatinib sensitivity (data not shown) suggesting that these metabolic features, although not associated with Dasatinib resistance might be a distinctive response to energetic stress among subsets. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.