Each OI diagnosed showed strong association with CD4 count less than 200/mm3; oral candidiasis (OR = 27.20, P < 0.001), tuberculosis (OR = 9.40, P < 0.001), skin fungal infections (OR = 11.10, P = 0.008) and pneumonia (OR = 8.21, P = 0.032) [Table 3]. This evidence concerns the gene CD4 and pneumonia.