Our previous studies have found that PRL-3 interacted with integrin α1, downregulated tyrosine phosphorylation of integrin β1, enhanced the phosphorylation of ERK1/2 and further increased the gelatinolytic activity of gelatinase MMP-2, thus finally promoted metastasis in colon cancer cells [4,17]. Here, PTP4A3 is linked to malignant colon neoplasm.