Among numerous secreted adipokines, some of them including nesfatin-1 [5], retinol binding protein 4 (RBP4) [6], omentin-1 [7], vaspin [8], and progranulin [9], provide an extensive network of communication both within adipose tissue and are implicated directly in the pathologies associated with metabolic syndrome [10]. The gene discussed is NUCB2; the disease is metabolic syndrome.