On the other hand, the decreased expression of Tm4 observed after down-modulation of CD133 in highly expressing cells allows to speculate on a more specific mechanism by which CD133 can promote invasiveness of tumor cells, taking into account that the expression of specific isoforms of the Tms family correlates with the metastatic potential of TNBC-derived cells [22]. The gene discussed is PROM1; the disease is neoplasm.