In a second network, GRAIL connects three genes that regulate bone formation - the osteoblast differentiation enhancer FAM5C[43]; NELL1, a regulator of osteoblast differentiation and ossification [44]; and TNFRSF11A, an essential mediator of osteoclast development [45] - and the pro-apoptotic gene BLID, frequently deleted in human breast, lung, ovarian, and cervical cancers [46]. The gene discussed is NELL1; the disease is cervical carcinoma.