This often results from abnormal mRNA splicing of WWOX, missing exons, loss of heterozygosity (LOH) and hypermethylation in numerous carcinomas [4-9].WWOX might play tumor-suppressor function through interaction with TNF, p53, Bcl-2, ErbB-4 and c-Jun [3,10-12]. Here, WWOX is linked to neoplasm.