A reduced expression of the autophagy-related protein Beclin-1, which is required for the early step of autophagosome formation [10], and co-localization of sequestosome 1/p62 (an adaptor protein with several functional domains to target polyubiquitinated protein cargo to autophagosomes), ubiquitin, and hyperphosphorylated tau in aggregates have been reported in the cortex and hippocampus of AD patients [11,12]. The gene discussed is SQSTM1; the disease is Alzheimer disease.