The knockdown of FLOT1 reportedly suppressed the proliferation and tumorigenesis of breast cancer cells by enhancing the transcriptional activity of FOXO3a, inhibiting Akt activity, downregulating cyclin D1 and upregulating the cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1[26]. This evidence concerns the gene CDKN1B and breast cancer.