Similarly, in rice miR827 is co-expressed with its targets, OsSPX-MFS1 and OsSPX-MFS2, in the same cells in response to P deficiency, where OsSPX-MFS1 is down-regulated and OsSPX-MFS2 is up-regulated in the plants [28]. The gene discussed is TGFBR2; the disease is hyperinsulinemic hypoglycemia, familial, 4.