There were no significant differences in mean ages, gender, tumor location, histological type, tumor depth, lymph node metastasis, retrieved lymph node number, vascular invasion, perineural invasion, pre-operative serum CEA level, and post-operative serum CEA level between patients with positive EGFR expression and those with negative EGFR expression. This evidence concerns the gene CEACAM5 and metastatic malignant neoplasm in the lymph nodes.