ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In particular, two single nucleotide polymorphisms (SNPs), the rs2241766 (+45 T > G) and rs266729 (−11377C > G), among others, have been extensively discussed as important determinants of total adiponectin levels [5,6], as well as risk for T2DM [5,7], MS [3,8], obesity [8] and coronary artery disease (CAD)/myocardial infarction (MI) [9-12] in different ethnic populations.