Histological features of ovaries in PCOS include the presence of more than 12 follicles smaller than 10 mm, surrounding the stroma, and an increase in the thickness of follicular theca and the ovarian stroma volume, which may be due to neoangiogenesis and vascular endothelial growth factor (VEGF) expression in the ovary [1,2]. The gene discussed is VEGFA; the disease is polycystic ovary syndrome.