Highlighting a few examples, Dysferlin (DYSF) is associated to muscular dystrophy [39], ATPase, Ca (2+)-transporting, plasma membrane, 1 (ATP2B1), where mouse knockouts have identified variation underlying embryonic lethality, and has a critical role in male fertility [40], Plakophilin 2 (PKP2), which is linked to circulatory system conditions [41, 42], and Cyclin A (CCNA2) that is an essential regulatory molecule for the cell’s cycle [43]. The gene discussed is ATP2B1; the disease is muscular dystrophy.