In a talk on sporadic proteopathies of the brain, Markus Krohn from Jens Pahnke`s group in Magdeburg reported on the role of ABC transporters in Alzheimer`s disease with a special focus on the effect of ABCB1 and ABCC1 regarding clearance mechanisms. This evidence concerns the gene ABCC1 and early-onset autosomal dominant Alzheimer disease.