In addition, SPAG9 was also shown to be associated with cellular proliferation, migration and invasion in squamous cell carcinoma-derived cervical cancer (SiHa) [12], renal cell carcinoma (Caki-1) [11] and colon cancer (COLO 205 and HCT 116) [13] cell line models, respectively. This evidence concerns the gene SPAG9 and hereditary clear cell renal cell carcinoma.