Recent genetic association studies on oral cancer risks have focused on the effects of single nucleotide polymorphisms in Excision repair cross-complimenting group 2 (ERCC2) gene, namely Xeroderma pigmentosum D (XPD), is an important DNA repair gene in nucleotide excision repair (NER) pathway which could repair a wide variety of structurally DNA lesions, including bulky adducts, cross-links [17], oxidative DNA damage, thymidine dimers [18] and alkylating damage [19]. Here, ERCC2 is linked to lip and oral cavity carcinoma.