Since we previously demonstrated that the expression of EPHRIN-A1 and SCINDERIN by tumor cells resulted in their resistance to the lysis by anti-tumoral CD8+ T cells [26], we analyzed the expression of EPHRIN-A1 and SCINDERIN in head and neck cancer patients and combined the study of these cytoskeletal biomarkers with CD8+ T cell infiltration. Here, CD8A is linked to neoplasm.