When we combined all the possible mechanisms of tumor resistance to CD8+ T cells (HLA class I loss, EPHRIN-A1 and SCINDERIN expression), patients with high CD8+ T cells infiltration expressing HLA-class I molecules on tumor cells and with low tumor expression of EPHRIN-A1 and SCINDERIN did not exhibit a better prognosis than the other groups of patients (data not shown). The gene discussed is SCIN; the disease is neoplasm.