Besides, the rs3729855_T (p.N352N) (1.52 (1.09–2.11) and rs17153743 (AG + GG) (2.30 (1.30–4.26); p = 0.005) were implicated in hypertension, while the former appeared to be protective against type 2 diabetes mellitus (0.68 (0.53–0.88); p = 0.003) (Table 2), also following the Bonferroni corrections for age, sex, and other confounders (Additional file 1, GATA4 Suppl data). This evidence concerns the gene GATA4 and hypertensive disorder.