First of all, we found a significant progressive loss of RKIP expression between normal pancreatic ductal epithelia (average: 73.76%), precursor lesions (PanINs; average: 36.71%), pancreatic cancer (average 20%) and matched lymph node metastases (average 8.3%; p < 0.0001). The gene discussed is PEBP1; the disease is familial pancreatic carcinoma.