RKIP loss in the main tumor body was marginally associated with higher T-stage (0.0599) as well as with the presence of peritumoral (0.0048) and intratumoral budding (p = 0.0373), while RKIP loss in the tumor buds exhibited a significant association with increased T stage (p = 0.0089). Here, PEBP1 is linked to neoplasm.