However, these molecules may affect HIV-1 infection in an opposite way as some, such as mannose-binding lectin (MBL) [22] and langerin [23], inhibit HIV-1 infection, while others, such as galectin-1, DC-SIGN [24], mannose receptor [25], syndecan-3 [26] and DCIR [27], increase the susceptibility to HIV-1 infection. This evidence concerns the gene CLEC4A and HIV-1 infection.