In the last experimental setting (high-dose ascorbate + hypoxia), 20 cell lines had a reduced GLUT-1 expression (heterogeneous pattern; most pronounced in the breast cancer cell lines) and 31 cell lines an increased GLUT-1 expression (most pronounced effect in ovarian and colon cancer cell lines; Fig. 6). This evidence concerns the gene SLC2A1 and colonic neoplasm.