However, the serum biochemical analysis showed that C66 treatment for 2 months significantly decreased the levels of the serum creatinine (Fig. S1B), serum ALB (Alb, Fig. 1B) and serum total protein (STP; Fig. 1C) induced by hyperglycaemia (P < 0.001), indicating that C66 administration attenuated the indexes of DN in mice. The gene discussed is ALB; the disease is Hyperglycemia.