INS and neuroblastoma: Starting from this knowledge and this background, we chose the neuroblastoma SH-SY5Y and the promyelocytic leukaemia line HL-60, both expressing insulin and insulin-like growth factor-1 (IGF-I) receptors [28, 33] to test some commercial Stevia extracts, in order to evaluate a possible effect of these compounds on glucose transport and to clarify the molecular mechanism of action.