CDKN1A and Miyoshi myopathy: Indeed, induction of β1-integrin mediated CAM-DR in MM cells was characterized by G1 cell cycle arrest accompanied by an increase in p27Kip1 protein level and decrease in enzymatic activity of cyclin A and cyclin E [208], upregulation of p21Cip1/Waf1 [149] or downregulation of Bim (the apoptotic BCL-2 family member) [213] implying involvement of posttranscriptional mechanisms.