As happens in MM cells [114], deletion/mutation in p53 or p14ARF (loss of function) or upregulation of MDM2 would direct the pathway toward deregulation of p53-related signaling pathways and downstream targets (p21, GADD45, Bax, Noxa, Puma), hence development of anti-apoptotic and DR signals. The gene discussed is MDM2; the disease is Miyoshi myopathy.