Translocation t(4;14) deranges at p16 locus the expression of FGFR3 which is a proto-oncogenic receptor tyrosine kinase, and multiple myeloma SET domain (MMSET) which apparently has methyl transferase function [23](readers are also referred to ref. [24] for FGFR3 biologic function). Here, FGFR3 is linked to plasma cell myeloma.