Increase in growth, proliferation, DR, CAM-DR and resistance to apoptosis mainly through activated STAT3, NFκB, Akt and MAPK pathways. Some HSPs (HSP27, HSP70) are upregulated following treatment of MM cells with proteasome inhibitors due to induction of stress response inducing DR and HSP90 inhibitors show synergism with bortezomib. In MM, HSPs can also stabilize antiapoptotic BCL-2 members (BCL-2, MCL-1 and BCL-XL), as HSP-90 inhibition in U266 cells resulted in significant apoptosis and downregulation of above proteins. This evidence concerns the gene AKT1 and Miyoshi myopathy.