Increase in growth, proliferation, DR, CAM-DR and resistance to apoptosis mainly through activated STAT3, NFκB, Akt and MAPK pathways. Some HSPs (HSP27, HSP70) are upregulated following treatment of MM cells with proteasome inhibitors due to induction of stress response inducing DR and HSP90 inhibitors show synergism with bortezomib. In MM, HSPs can also stabilize antiapoptotic BCL-2 members (BCL-2, MCL-1 and BCL-XL), as HSP-90 inhibition in U266 cells resulted in significant apoptosis and downregulation of above proteins. The gene discussed is BCL2; the disease is Miyoshi myopathy.