Furthermore, overexpression of c-MAF was detected in 50% of MM primary samples and also in HMCLs lacking c-MAF translocations and was associated with increase in ITGB7 (integrin β7) gene which is involved in adhesion of MM cells to BMSCs and induction of CAMDR [211, 224]. The gene discussed is ITGB7; the disease is Miyoshi myopathy.