In contrast, a slight phospho-AKT increase in KBr4 as well as very high levels shown in KBr3, could explain the gain in proliferation rates (Additional file, Figure 2A) in presence of ASCs, although it was not sufficient to promote tumor growth and aggressiveness, suggesting low c-Met expressing cells as cancer cells with a low tumorigenic behaviour (Figure 6C). The gene discussed is AKT1; the disease is neoplasm.