Increased migratory capabilities in KBr1 and KBr2 cells, suggested they could have acquired a metastatic signature, defined by expression of specific genes as twist1, snail1, frequently overexpressed in cancer cells with high metastatic potential [37, 38], as well as c-MET receptor and its co-receptor CD44v6, associated with highly invasive breast cancer and poor outcome [39]. The gene discussed is TWIST1; the disease is cancer.