CD44 and neoplasm: Indeed, we found CD44+/CD24−/low subpopulation of breast cancer cells increased in presence of ASCs (Figure 7F), suggesting HGF/c-Met mediated crosstalk could exacerbate tumorigenic potential and aggressiveness of tumor cells, increasing the amount of those cells displaying stem like features, well known to be associated with acquired chemoresistance, tumor spreading and higher metastatic potential [42, 21] accounting for tumor recurrence.