Despite the development of targeted therapies directed against “driver” mutations in EGFR and ALK, nearly 50% of non-small cell lung carcinomas (NSCLC) currently lack identifiable mutations in these sites and therefore more targets beyond DNA mutation analysis including DNA methylation, mRNA and micro RNA expression analysis are a focus of investigations in lung cancer and other malignancies[2-6]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.