Interestingly, a subset of BWS patients with IC2 epimutations also harbour epimutations at other imprinted gene cluster DMRs outside of 11p15.5 (for example, PLAGL1 and MEST (PEG1) on chromosomes 6 and 7 respectively) [7,8]. This evidence concerns the gene PLAGL1 and Beckwith-Wiedemann syndrome.