IGF2 and Beckwith-Wiedemann syndrome: For example, gain of methylation (GOM) at the normally unmethylated maternal allele of the chromosome 11p15.5 IC1 DMR is associated with bi-allelic expression of the paternally expressed growth promoter IGF2 and is associated with the Beckwith-Wiedemann congenital overgrowth syndrome (BWS) [4].