As shown in Table 1 the expression of E-cadherin was not correlated with age (P =1.000), sex (P =0.494), expression of Ki 67 (P =0.356) but correlated with histological grade (P < 0.01) and lymph node metastasis (P < 0.01). The gene discussed is CDH1; the disease is metastatic malignant neoplasm in the lymph nodes.