Based on the results of studies of glioblastoma, PTEN, a regulator of PI3K/AKT signaling, appears to function as a crucial inhibitor of proliferation of CSCs and as an inducer of senescence, suggesting that the PTEN/PI3K/AKT axis is a fundamental signaling pathway in glioblastoma stem cells [105]. Here, AKT1 is linked to glioblastoma.