Additionally, investigators observed a strong association between the expression of Gli2 and that of FOXM1 in HCC cells, which is consistent with the concept that in human HCC cases, the SHH signaling pathway is involved in differentiation and proliferation of tumor cells, in part via induction of nuclear accumulation of Gli2 and subsequent upregulation of expression of FOXM1 [112]. Here, SHH is linked to hepatocellular carcinoma.