Furthermore, GANT-61 inhibits PCSC-containing tumor growth, which is associated with upregulation of TRAIL-R1/DR4 and TRAIL-R2/DR5 expression and downregulation of Gli-1, Gli-2, Bcl-2, and ZEB1 expression in tumor samples obtained from nude mouse xenografts [77]. The gene discussed is GLI1; the disease is neoplasm.