EDN1 and neoplasm: Decreased expression of genes whose products are responsible for activation of neutrophils and/or granulocytes (such as complement components, endothelin 1, IL-15, integrin β2, monocyte chemoattractant protein 1, macrophage inflammatory protein 4α, protein kinase C inhibitor 2, GTP-binding protein Ram, and monocyte differentiation antigen CD14) point to a decreased capacity of SiHaCDV cells to activate and attract neutrophils and macrophages at the tumor site compared to SiHaparental.