Here, we demonstrate MMP7 is an important target downstream of DKK1 in HCC cells, based on the following studies: overexpression of DKK1 or upon GSK3β inhibitor treatment is associated with enhanced level of MMP7, migration and invasion in HCC cells, whereas knockdown of DKK1 by shRNA represses MMP7 expression and inhibits migration and invasion of HCC cells. This evidence concerns the gene GSK3B and hepatocellular carcinoma.