Our previous study demonstrated that, in stages I-II and operable stage III breast cancer patients, hormone receptor- (HR-) positive premenopausal patients with the long allele of the CYP19 polymorphism have a significantly better DFS and OS than those without the long allele, but this prognostic effect of the CYP19 polymorphism is not seen in postmenopausal women patients [8]. The gene discussed is NR4A1; the disease is breast carcinoma.