Although its role in BCC is not fully understood, it has been suggested that TGF-β increases the proliferation and promotes Epithelial-Mesenchymal transition (EMT) of the tumor cells, a process that will be discussed later in this article, and it also inhibits apoptosis of the surrounding active stroma, resulting in BCC progression.29,30. This evidence concerns the gene TGFB1 and neoplasm.