Accordingly, T. cruziacutely-infected mice exhibit an intense thymic atrophy mainly characterized by a massive loss ofcortical CD4+CD8+ thymocytes and an aberrant output of immature Tcells, which have likely bypassed the negative selection process and may be involved with thegeneration of T cell autoimmune events seen in both murine and human Chagas disease [3]–[5]. The gene discussed is CD8A; the disease is Chagas disease.